English Synonyms and Antonyms
in spite ofprep
Notwithstanding simply states that circumstances shall not be or have not been allowed to withstand; despite and in spite of refer primarily to personal and perhaps spiteful opposition; as, he failed notwithstanding his good intentions; or, he persevered in spite of the most bitter hostility. When despite and in spite of are applied to inanimate things, it is with something of personification; "in spite of the storm" is said as if the storm had a hostile purpose to oppose the undertaking.
despite, notwithstanding, notwithstanding