What is another word for pernica?

Synonyms for pernica
per·ni·ca

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permutations, permute, permyriad, pernambuco wood, Pernell Roberts, pernica, pernicious, pernicious anaemia, pernicious anemia, perniciously, perniciousness

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An antonym of "besotted"
A indifferent
B stringent
C flush
D affluent