What is another word for premedicated?

Synonyms for premedicated
pre·med·i·cat·ed

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premature labour, premature ventricular contraction, prematurely, prematureness, prematurity, premedicated, premeditate, premeditated, premeditation, premenstrual syndrome, premenstrual tension

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An antonym for the term "Ductile"?
A fictile
B pliable
C malleable
D intractable