What is another word for cardinal symptom?

Synonyms for cardinal symptom
car·di·nal symp·tom

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cardinal flower, cardinal grosbeak, cardinal number, cardinal point, cardinal points, cardinal symptom, cardinal tetra, cardinal vein, cardinal virtue, cardinal virtues, cardinalate

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Which of the following words is not a synonym of the others?
A harmlessly
B detrimentally
C noxiously
D harmfully