What is another word for directed molecular evolution?

Synonyms for directed molecular evolution
di·rect·ed molec·u·lar evo·lu·tion

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direct-grant school, directed, directed acyclic word graph, directed edge, directed graph, directed molecular evolution, directed path, directed verdict, directeur, directeurs, directing

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Which of the following terms is not a synonym for "Tolerable"?
A adequate
B fair to middling
C passable
D constructive